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US 5,290,561 AGranted
Single layer transdermal drug administration system
AssigneeG. D. Searle & Co.
InventorsBahram Farhadieh, Rajeev D. Gokhale
Life of this patent
Estimating the term…
Abstract
A patch for the transdermal delivery of pharmaceutical drugs. The patch is characterized by having a single mass of elastomer in which the active drug and a percutaneous absorption enhancer are homogeneously dispersed throughout. The patch is especially well suited to delivering the beta.sub.2 adrenergic agonist drug albuterol.
Claims24
A monolayer patch for the transdermal administration of albuterol comprising:
- a. room temperature vulcanizable organopolysiloxane rubber Silastomer X7-3058 in an amount ranging from about 25 to about 95 per cent, weight to weight;
- b. albuterol in an amount ranging from about 2 to about 30 per cent, weight to weight;
- and
- c. a diffusion enhancer, said diffusion enhancer being a normal hydrocarbon alcohol having from about 1 to about 20 carbon atoms, and said diffusion enhancer being present in an amount ranging from about 3 to about 30 per cent, weight to weight.
1 more element
A monolayer patch for the transdermal administration of albuterol comprising:
- a. an elastomeric matrix present in an amount ranging from about 25 to about 95 per cent, weight to weight;
- b. albuterol in an amount ranging from about 2 to about 30 per cent, weight to weight;
- c. a diffusion enhancer, said diffusion enhancer being a normal hydrocarbon alcohol having from about 1 to about 20 carbon atoms, and said diffusion enhancer being present in an amount ranging from about 3 to about 30 per cent, weight to weight;
- and
- d. a curing catalyst for said elastomeric matrix selected from stannous 2-ethylkhexoate or curing catalyst X7-3075, and said curing catalyst being present in an amount ranging from about 0.0625 to about 0.5 per cent, weight to weight.
2 more elements
Dependencies are inferred from the claim text.