Surface modified ocular implants, surgical instruments, devices, prostheses, contact lenses and the like
AssigneeUniversity of Florida
InventorsEugene P. Goldberg, Ali Yahiaoui, Khalid Mentak
Life of this patent
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Abstract
A method for modifying the plastic surface of an article adapted for contacting living tissue by the gamma or electron beam irradiation induced chemical graft coating thereon of: (1) a neutral or ionic water-soluble, hydrophilic vinylic monomer or salt thereof; (2) a mixture of at least two of said monomers, or (3) a mixture of (1) or (2) with up to about 50%, by weight, based on the total monomer weight, of a member selected from the group consisting of N-vinylpyrrolidone, 2-hydroxyethyl-methacrylate, and mixtures thereof; so as to form a hydrophilic graft polymer coating on the surface.
Claims17
A method for modifying a plastic surface of an article, said surface adapted for contact with living tissue of a human or non-human animal, by the gamma irradiation induced polymerized chemically grafted coating thereon of:
- (1) a neutral or ionic water-soluble, hydrophilic, vinylic monomer or salt thereof;
- (2) a mixture of at least two of said monomers, or
- (3) a mixture of (1) or (2) with up to about 50%, by weight, based on the total monomer weight, of a member selected from the group consisting of N-vinylpyrrolidone, 2-hydroxyethyl-methacrylate, and mixtures thereof;
- so as to form a hydrophilic graft polymer coating on said surface comprising:
- conducting said gamma irradiation induced graft polymerization in an aqueous solution under the following conditions:
- a) total monomer concentration in the range of from about 0.1% to about 50%, by weight;
- b) total gamma dose in the range of from about 0.001 to less than about 0.50 Mrad;
- and
- c) gamma dose rate in the range of from about 10 to about 2,500 rads/min.
A method for modifying a plastic surface of an article, said surface adapted for contact with living tissue of a human or non-human animal, by the one-step electron beam-irradiation induced polymerized chemically grafted coating thereon of:
- (1) a neutral or ionic water-soluble, hydrophilic, vinylic monomer or salt thereof;
- (2) a mixture of at least two of said monomers, or
- (3) a mixture of (1) or (2) with up to about 50%, by weight, based on the total monomer weight, of a member selected from the group consisting of N-vinylpyrrolidone, 2-hydroxyethyl-methacrylate, and mixtures thereof;
- so as to form a hydrophilic graft polymer coating on said surface comprising:
- conducting said electron beam-irradiation induced graft polymerization in an aqueous solution of at least one of said monomers under the following conditions:
- (a) monomer concentration in the range of from about 0.1% to about 50%, by weight;
- (b) total electron beam irradiation dose equivalent to a gamma irradiation dose in the range of from about 0.001 to less than about 0.50 Mrad;
- and
- (c) an electron beam irradiation dose rate equivalent to a gamma irradiation dose rate in the range of from about 10 to about 10.sup.8 rads/min.
Dependencies are inferred from the claim text.