Test for the rapid evaluation of ischemic states and kit
AssigneeDiagnostic Markers, Inc.
InventorsDavid Bar-Or, Clive Solomons
Life of this patent
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Abstract
A method for detecting ischemic states in a patient by contacting a sample of serum, plasma, fluid or tissue with a metal ion capable of binding to metal ion binding sites in the sample to form a mixture, and then detecting the presence of unbound metal ions to determine the occurrence of ischemia. The reagents required to perform the method are incorporated into a test kit.
Claims18
A kit for detecting the occurrence of non-occurrence of an ischemic event in a patient, said kit consisting essentially of a metal salt, wherein said salt contains a metal ion selected from the group consisting of V, As, Co, Sb, Cr, Mo, Mn, Ba, Zn, Ni, Hg, Cd, Fe, Pb, Au and Ag, and a color forming compound capable of forming a colored compound with said metal salt, wherein said color forming compound is a C.sub.2-6 alkyl thioalcohol, C.sub.2-6 alkyl thioamine, C.sub.2-10 alkyl thiomonocarboxylic acid, C.sub.2-10 alkyl thiodicarboxylic acid, C.sub.2-10 alkyl dithio-dicarboxylic acid, di-C.sub.1-6 alkyl dithiocarbamic acid, thiol-containing amino acid, thiol-containing peptide, thiol-containing enzyme, metal hydroxide, ammonium hydroxide, metal cyanide or ammonium thiocyanate.
A kit for detecting the occurrence or non-occurrence of an ischemic event in a patient, said kit consisting essentially of a metal salt, wherein said salt contains a metal ion selected from the group consisting of V, As, Co, Sb, Cr, Mo, Mn, Ba, Zn, Ni, Hg, Cd, Fe, Pb, Au and Ag, and a color forming a compound capable of forming a colored compound with said metal salt, wherein said color forming compound is a C.sub.2-6 alkyl thioalcohol, C.sub.2-6 alkylthio amine, C.sub.2-10 alkyl thiomonocarboxylic acid, C.sub.2-10 alkyl thiodicarboxylic acid, C.sub.2-10 alkyl dithio-dicarboxylic acid, di-C.sub.1-6 alkyl dithiocarbamic acids, thiol-containing amino acid, thiol-containing peptide, thiol-containing enzyme or ammonium thiocyanate.
Dependencies are inferred from the claim text.