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US 5,288,888 AGranted
Process for the synthesis of acetic acid, (dimethoxyphosphinyl) [[1,1-dimethylethyl)dimethylsilyl]-oxy]-, (4-nitrophenyl) methyl ester
AssigneeAmerican Cyanamid Company
InventorsKenneth E. Green, Edward R. Ruso, Mellard N. Jennings, Alex R. Jurgens, David M. Blum, Gregg B. Feigelson
Life of this patent
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Abstract
The invention is an improved process for the large scale production of acetic acid, (dimethoxyphosphinyl) [[1,1-dimethylethyl)dimethylsilyl]oxy]-, (4-nitrophenyl)methyl ester.
Claims8
A process for the preparation of a compound of the formula:
- ##STR3## which comprises the steps of (a) reaction of L-tartaric acid of the formula:
- ##STR4## with p-nitrobenzylbromide in the presence of an amine in a solvent to the corresponding bis-(4-nitrophenyl)-ester of the formula:
- ##STR5## (b) oxidizing the bis-(4-nitrophenyl)ester with an oxidant in a solvent to product the dihydroxyacetic acid 4-nitrophenyl ester of the formula:
- ##STR6## (c) reacting the dihydroxyacetic acid 4-nitrophenyl ester with dimethylphosphite in a solvent to produce the dimethoxyphosphinyl compound of the formula:
- ##STR7## (d) reacting the dimethoxyphosphinyl compound with t-butyldimethylsilyl chloride in a solvent in the presence of a base to afford the desired compound of the formula:
- ##STR8##
3 more elements
Dependencies are inferred from the claim text.