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US 5,288,870 AGranted
Synthesis of specifically labeled tetrodotoxin
AssigneeThe Research Foundation of State University of New York
InventorsChien-yuan Kao, Biqi Wu
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Abstract
The present invention relates to a process for the preparation of specifically labelled TTX of high specific activity. In the present process, TTX is oxidized by use of the Pfitzer-Moffat method or Fenton's reagent and the aldehyde obtained is hydrated. The hydrated aldehyde is reduced with alkali metal o alkaline earth metal borotritide. The radioactive TTX so obtained, quite surprisingly, has a specific activity many times greater than previously prepared radioactive TTX.
Claims13
A process for the preparation of labeled tetrodotoxin having high specific activity comprising the steps of:
- a) oxidizing tetrodotoxin to 11-oxo-tetrodotoxin;
- b) hydrating the 11-oxo-tetrodotoxin;
- c) reducing the hydrated 11-oxo-tetrodotoxin with an alkali metal or alkaline earth metal tritide.
Dependencies are inferred from the claim text.