Potassium clavulanate in rosette form
AssigneeBeecham Group Limited
InventorsDennis E. Clark, Shaukat H. Malik, Paul G. Butterly, Clive E. Badman, Jeffrey D. Haseler
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Abstract
Potassium clavulanate exists in a novel crystalline habit, namely in the form of rosettes, having improved processing properties. The novel form may, for example, be obtained by crystallization or recrystallization using inverse precipitation, preferably at 8.degree.-15.degree. C.
Claims11
Potassium clavulanate in a crystalline form, of which 50% by weight or more of the potassium clavulanate is in the form of crystalline rosettes, each rosette comprising a plurality of needle crystals radiating out from a common nucleation point and characterized by their microscopic appearance under 100-fold magnification as having a clearly discernible rosette-form.
A process for the preparation of potassium clavulanate in the form of crystalline rosettes which comprises dissolving potassium clavulanate in aqueous methanol, ethanol or isopropanol and admixing the resulting solution with a mixture of isopropanol and acetone so as to cause precipitation of the potassium clavulanate in the form of crystalline rosettes.
Dependencies are inferred from the claim text.