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US 5,288,852 AGranted
Human tumor necrosis factor polypeptides
AssigneeDainippon Pharmaceutical Co., Ltd.
InventorsMasaaki Yamada, Yasuji Furutani, Mitsue Notake, Juniti Yamagishi
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Abstract
A novel cloned DNA encoding a human tumor necrosis factor (TNF), a vector having said DNA inserted thereinto, a host transformed with said vector and a novel human TNF polypeptide, and processes for producing them.
Claims4
A polypeptide having human tumor necrosis factor activity and being selected from the group consisting of
- (a) the polypeptide having the amino acid sequence of the following formula, and
- (b) a polypeptide having an amino acid sequence resulting from the addition of one or two amino acid residues from the precursor portion of said polypeptide (a) to the N-terminus of the following formula:
- ##STR131##
A human tumor necrosis factor precursor polypeptide having the following amino acid sequence:
- ##STR133## or the said polypeptide having a methionine residue at the N-terminus.
Dependencies are inferred from the claim text.