Tertiary and secondary amines as alpha-2 antagonists and serotonin uptake inhibitors

A compound or pharmaceutically acceptable salt thereof having the structure ##STR23## wherein B is hydrogen or alkyl of from one to three carbon atoms;

• R.sub.1 is alkoxy of from one to four carbon atoms;
• R.sub.2 is hydrogen or, taken together with R.sub.1 is methylenedioxy or ethylenedioxy;
• R.sub.3 is hydrogen, fluorine, or chlorine, and
• D is selected from the group consisting of ##STR24## wherein R.sub.7 is one, two or three substituents independently selected from the group consisting of hydrogen, alkyl of from one to four carbon atoms, halogen, hydroxy, alkoxy of from one to four carbon atoms, amino, and thioalkoxy of from one to four carbon atoms;
• and
• R.sub.8 is selected from hydrogen, lower alkyl and alkylsulfonyl.