Quinolylmethoxyphenylacetic acid acylamides and ureas
AssigneeBayer Aktiengesellschaft
InventorsSiegfried Raddatz, Klaus-Helmut Mohrs, Michael Matzke, Romanis Fruchtmann, Armin Hatzelmann, Reiner Muller-Peddinghaus
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Abstract
Quinolylmethoxyphenylacetic acid acylamides and ureas can be prepared either by reacting corresponding carboxylic acids with amides or reacting corresponding amides with isocyanates or ureas. The quinolylmethoxyphenylacetic acid acylamides or ureas can be used as active compounds in medicaments.
Claims8
Aquinolylmethoxyphenyl acetic acid acylamide or urea of the formula ##STR13## in which A, B, D, E, G, L and M independently of one another represent hydrogen, hydroxyl, halogen, cyano, carboxyl, nitro, trifluoromethyl or trifluoromethoxy, or represent straight-chain or branched alkyl or alkoxy having in each case up to 8 carbon atoms, or represent aryl having 6 to 10 carbon atoms, which is optionally substituted by halogen, hydroxyl, nitro or cyano,
- R.sup.1 represents cycloalkyl having 3 to 12 carbon atoms, which is optionally substituted by straight-chain or branched alkyl having up to 8 carbon atoms,
- R.sup.2 represents hydrogen, straight-chain or branched alkyl having up to 6 carbon atoms or benzyl and
- R.sup.3 represents straight-chain or branched alkyl having up to 8 carbon atoms, benzyl, cycloalkyl having 3 to 12 carbon atoms or phenyl, which is optionally substituted by halogen, nitro, cyano or hydroxyl, or represents a group of the formula --NR.sup.4 R.sup.5, wherein
- R.sup.4 and R.sup.5 are identical or different and denote hydrogen, straight- chain or branched alkyl having up to 6 carbon atoms, benzyl or phenyl,
- or a physiologically acceptable salt thereof.
Dependencies are inferred from the claim text.