A composition and a method of using veratridine and epinephrine as a local anesthetic
AssigneeThe Brigham and Women's Hospital, Inc.
InventorsGary R. Strichartz, Sanjay Datta, Markus Schneider
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Abstract
A method of using veratridine to inhibit nerve impulses, and a composition of matter including veratridine and epinephrine, is provided. Application of veratridine proximal to a nerve causes depolarization of the nerve membrane, thereby blocking transmission of nerve impules. C-fiber selectivity is demonstrated in vitro in rabbit vagus nerves. Veratridine displays extended anesthetic activity over long periods of time when compared to similar local anesthetics, with no local toxicity. Systemic toxicity is reduced by co-injection with epinephrine.
Claims6
A method for inhibiting nerve impulses in an animal or human in need thereof comprising administering a therapeutically effective amount of veratridine or a pharmaceutically acceptable salt thereof, proximal to at least one C-fiber containing nerve.
A method for inhibiting nerve impulses comprising administering to an animal in need of such treatment and proximal to said C-fiber containing nerve an effective amount of a compound having the formula:
- ##STR2## or a pharmaceutically acceptable salt thereof.
A composition of matter comprising a therapeutically effective amount of veratridine or a pharmaceutically acceptable salt thereof in combination with an amount of epinephrine effective to mitigate the toxic side effects of veratridine.
Dependencies are inferred from the claim text.