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US 5,288,720 AGranted
Angiotensin II receptor blocking 2,3,6 substituted quinazolinones
AssigneeAmerican Cyanamid Company
InventorJay D. Albright
Life of this patent
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Abstract
Novel 2, 3, 6 substituted quinazolinones of the formula: ##STR1## wherein R, R.sup.6 and X are described in the specification are disclosed. The compounds which have activity as angiotensin II (AII) antagonists.
Claims38
A quinazolinone compound having the formula:
- ##STR36## wherein:
- R is ##STR37## X is straight or branched alkyl of 3 to 5 carbon atoms;
- R.sup.6 is ##STR38## R.sup.2 is H, or straight chain lower alkyl of 1 to 4 carbon atoms;
- R.sup.3 is ##STR39## n is 2,S or 4;
- m is 3 or 4;
- R.sup.4 is H, or straight chain lower alkyl of 1 to 4 carbon atoms;
- R.sup.5 is straight chain lower alkyl of 1 to 4 carbon atoms;
- and the pharmaceutically acceptable salts thereof.
5 more elements
A quinazolinone compound having the formula:
- ##STR41## wherein:
- X is straight or branched alkyl of 3 to 5 carbon atoms;
- R.sup.6 is ##STR42## R.sup.2 is H, or straight chain lower alkyl of 1 to 4 carbon atoms;
- R.sup.3 is ##STR43## n is 2, 3 or 4;
- m is 3 or 4;
- R.sup.4 is H, or straight chain lower alkyl of 1 to 4 carbon atoms;
- R.sup.5 is straight chain lower alkyl of 1 to 4 carbon atoms;
- ##STR44##
5 more elements
A quinazolinone compound having the formula:
- ##STR46## wherein X is straight or branched alkyl of 3 to 5 carbon atoms;
- R.sup.6 is ##STR47## R.sup.2 is H or straight chain lower alkyl of 1 to 4 carbon atoms;
- R.sup.3 is ##STR48## n is 2, 3 or 4;
- m is 3 or 4;
- R.sup.4 is H, or straight chain lower alkyl of 1 to 4 carbon atoms;
- R.sup.5 is straight chain lower alkyl of 1 to 4 carbon atoms.
3 more elements
The compound according to claim, 1, 2-butyl-6-[hydroxy(1-methyl-2-oxo-3-pyrrolidinyl)methyl]-3-[[2'-(1H-tetraz ol-5yl)[1,1'-biphenyl]-4-yl]methyl]-4(3H) quinazolinone.
Dependencies are inferred from the claim text.