2-,3-,8-and/or 10-substituted dibenzoxazepine compounds, pharmaceutical compositions and methods for treating osteoporosis

Abstract

The present invention provides a method for treating osteoporosis in a mammal comprising administering to said mammal a therapeutically-effective amount of a 2-, 3-, 8- and/or 10-substituted dibenzoxazepine compound having a structure of the formula: ##STR1## or a pharmaceutically-acceptable salt thereof, wherein: X is --NH-- or --CH.sub.2 --; Y is (1) --CH.sub.2 -- when X is --NH--, and (2) --NH-- when X is --CH.sub.2 --; R.sup.1 is hydrogen, halogen or --OR.sup.4 ; R.sup.4 is hydrogen, alkyl or ##STR2## Z is oxygen, sulfur, --SO--, --SO.sub.2 -- or --NR.sup.5 --; R.sup.5 is hydrogen or t-butyloxycarbonyl; R.sup.2 is hydrogen, halogen or trifluoromethyl; R.sup.3 is hydrogen, halogen, aryl, heteroaryl in which the heteroatoms are selected from oxygen, nitrogen and/or sulfur, or --NR.sup.6 R.sup.7 ; R.sup.6 and R.sup.7 are each independently hydrogen or alkyl; R.sup.8 is alkyl, aryl or ##STR3## R.sup.9 and R.sup.10 are each independently hydrogen or alkyl, or when taken together form N-morpholino or 4-methyl-N-piperazinyl; m and n are each independently integers of from 0 to 3; and P is 0 or 1, provided that p is not 1 when m is 0.

Dependencies are inferred from the claim text.