Synergistic composition comprising a fibroblast growth factor and a sulfated polysaccharide, for use as antiviral agent
AssigneeFarmitalia Carlo Erba S.p.A.
InventorsDomenico Ungheri, Luisa Garofano, Carlo Battistini, Paolo Carminati, Guy Mazue
Life of this patent
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Abstract
A pharmaceutcial composition is provided for use in the prevention or treatment of viral infections caused by enveloped viruses. The composition comprises a fibroblast growth factor, a sulfated polysaccharide with antiviral activity, and one or more pharmaceutically acceptable carriers. The fibroblast growth factor may be a basic fibroblast growth factor or an analogue thereof, and the polysaccharide may be a carrageenan, heparin, dextran sulfate, pentosan polysulfate or a sulfated polysaccharides produced by marine algae belonging to the class of Rhodophyceae.
Claims14
A pharmaceutical composition, comprising an amount of:
- (i) a fibroblast growth factor selected from the group consisting of an amidated human or bovine fibroblast growth factor, a human or bovine fibroblast growth factor having an N-terminal extension selected from the group consisting of SEQ ID NOS:2, 3, 4 and 5, an amidated human or bovine fibroblast growth factor having an N-terminal extension selected from the group consisting of SEQ ID NOS:2, 3, 4 and 5, the peptides of SEQ ID NOS:8, 9, 10, 11, 12, 13, 14 and 15, amidated peptides of SEQ ID NOS:8, 9, 10, 11, 12, 13, 14 and 15, and mixtures thereof;
- (ii) a sulfated polysaccharide having antiviral activity;
- and
- (iii) a pharmaceutically acceptable excipient, effective for the treatment or prevention of infections caused by enveloped viruses.
A pharmaceutical composition, comprising an amount of:
- (i) a fibroblast growth factor,
- (ii) carrageenan, pentosan polysulfate, dextran polysulfate, a sulfated polysaccharide produced by marine algae of the class Rhodopyceae, or a mixture thereof, and
- (iii) a pharmaceutically acceptable excipient, effective for the treatment or prevention of infections caused by enveloped viruses.
Dependencies are inferred from the claim text.