Back to results
US 5,288,640 AGranted
Sequences containing the vpu gene and vectors therefore methods of preparation and use
AssigneeDana-Farber Cancer Institute, Inc.
InventorsWilliam A. Haseltine, Ernest Terwilliger, Eric Cohen
Life of this patent
Estimating the term…
Abstract
DNA segments encoding the vpu gene and a vector encoding the vpu gene are disclosed. These sequences containing the vpu gene can be used to express a protein that has antigenic determinants that can be used to screen for people having the HIV-1 virus.
Claims5
A DNA segment encoding an HIV-1 vpu gene product, wherein the DNA segment does not encode an entire HIV env gene product.
A vector comprising:
- (a) a DNA segment comprising a sufficient number of nucleotides corresponding to nucleotides in region 5541-8017 of the HIV-1 genome, wherein an AUG codon is inserted immediately upstream and in proper reading frame with said region to encode an HIV-1 vpu viral protein, wherein the DNA segment does not encode an entire HIV env gene product;
- and
- (b) a promoter upstream of the DNA segment.
Dependencies are inferred from the claim text.