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US 5,288,620 AGranted
Process for the production of optically active 2-hydroxy-4-phenyl-3-butenoic acid
AssigneeDaicel Chemical Industries, Ltd.
InventorsAkinobu Matsuyama, Ichiro Takase, Yoichiro Ueda, Yoshinori Kobayashi
Life of this patent
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Abstract
Optically active 2-hydroxy-4-phenyl-3-butenoic acid can be obtained by treating 2-oxo-4-phenyl-3-butenoic acid with an optionally treated microorganism capable of asymmetrically reducing the 2-oxo-4-phenyl-3-butenoic acid into (R)-2-hydroxy-4-phenyl-3-butenoic acid or (S)-2-hydroxy-4-phenyl-3-butenoic acid to thereby asymmetrically reduce the same into (R)-2-hydroxy-4-phenyl-3-butenoic acid or (S)-2-hydroxy-4-phenyl-3-butenoic acid.
Claims2
A process for the production of optically active 2-hydroxy-4-phenyl-3-butenoic acid, which comprises:
- treating a microorganism selected from the group of genera consisting of Lactobacillus, Leuconostoc, Streptococcus, Sporolactobacillus, Pediococcus, Arthrobacter, Agrobacterium, Ambrosiozyma, Achromobacter, Arthroascus, Aureobacterium, Bacillus, Botryoascus, Brevibacterium, Candida, Clavispora, Corynebacterium, Flavobacterium, Geotrichum, Hansenula, Kluyveromyces, Lipomyces, Lodderomyces, Proteus, Pseudomonas, Saccharomycopsis, Schizosaccharomyces, Stephanoascus, Torulaspora, Trigonopsis, Wickerhamiella, Enterobacter, Klebsiella and Xanthomonas by a treatment selected from the group consisting of grinding, treating with acetone and lyophilizing, to obtain an enzyme preparation having the biochemical activity of reducing 2-oxo-4-phenyl-3-butenoic acid to form (S)-2-hydroxy-4-phenyl-3-butenoic acid or (R)-2-hydroxy-4-phenyl-3 butenoic acid;
- and
- treating 2-oxo-4-phenyl-3-butenoic acid with said enzyme preparation.
Dependencies are inferred from the claim text.