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US 5,288,506 AGranted
Antacid compositions with prolonged gastric residence time
AssigneeWalton S.A.
InventorsRobert G. W. Spickett, Jose L. F. Vidal, Juan C. Escoi
Life of this patent
Estimating the term…
Abstract
Antacid powders, tablets etc. of prolonged gastric residence time have an internal phase of a solid antacid and excipient surrounded by a solid external phase containing a hydrophobic substance e.g. an ester of glycerol with palmitic or stearic acid, a hydroxylated polyalkene and a non-ionic emulsifier.
Claims10
A solid pharmaceutical preparation comprising an internal phase and a solid external phase,
- a) the internal phase being a powder mixture comprising discrete solid granules of an antacid means for neutralizing acid and a pharmaceutically acceptable excipient,
- b) the internal phase being surrounded by a solid external phase comprising a hydrophobic organic means for floating selected from the group consisting of hydrogenated mono-, di- and tri-glycerides, wherein about 70% to 90% by weight of ester is a 12-hydroxysteric ester and about 10 to 20% by weight of ester is a stearic acid ester, a hydroxylated polyalkene having a molecular weight between about 950 and about 10,000, and a non-ionic emulsifier comprising a polyoxyethylene-sorbitan mono-ester of an oleic, lauric, stearic or palmitic acid.
A solid pharmaceutical preparation consisting essentially of an internal phase and a solid external phase,
- a) said internal phase comprising an antacid means for neutralizing acid and a pharmaceutically acceptable excipient, and
- b) the internal phase being surrounded by a solid external phase comprising a hydrophobic organic means for floating selected from the group consisting of hydrogenated mono-, di- and tri-glyceride, wherein about 70 to 90% by weight of ester is a 12-hydroxystearic ester and about 10 to 30% by weight of ester is a stearic acid ester, a hydroxylated polyalkene having a molecular weight between about 950 and about 10,000, and a non-ionic emulsifier comprising a polyoxyethylene-sorbitan mono-ester of an oleic, lauric, stearic or palmitic acid.
A solid pharmaceutical preparation comprising an internal phase and a solid external phase,
- a) the internal phase being a powder mixture of discrete solid granules of an antacid means for neutralizing acid selected from the group consisting of aluminum magnesium hydroxycarbonates and sulphates and a pharmaceutically acceptable excipient,
- b) the internal phase being surrounded by a solid external phase comprising a hydrophobic organic means for floating selected from hydrogenated mono-, di- or tri-glycerides, in which from about 70 to 90% by weight of the ester is a 12-hydroxysteric ester and about 10 to 30% by weight of ester is a stearic acid ester, a hydroxylated polyalkene having a molecular weight between about 950 and 10,000, and a non-ionic emulsifier.
A solid pharmaceutical preparation comprising an internal phase and a solid external phase,
- a) the internal phase being a powder mixture comprising discrete solid granules of an antacid means for neutralizing acid, a gastric acid secretion inhibitor selected from the group consisting of cimetidine, ranitidine and omeprazole, and a pharmaceutically acceptable excipient,
- b) the internal phase being surrounded by a solid external phase comprising a hydrophobic organic means for floating selected from the group consisting of hydrogenated mono-, di- or tri-glycerides, wherein about 70 to 90% by weight of the ester is a 12-hydroxysteric ester and about 10 to 30% by weight of ester is a stearic acid ester, a hydroxylated polyalkene having a molecular weight between about 950 and about 10,000, and a non-ionic emulsifier comprising a polyoxyethylene-sorbitan mono-ester of an oleic, lauric, stearic or palmitic acid.
A solid pharmaceutical preparation comprising an internal phase and a solid external phase,
- a) the internal phase being a powder mixture of discrete solid granules of an antacid means for neutralizing acid selected from the group consisting of aluminum magnesium hydroxycarbonates and sulphates, a gastric acid secretion inhibitor selected from the group consisting of cimetidine, ranitidine and omeprazole, and a pharmaceutically acceptable excipient,
- b) the internal phase being surrounded by a solid external phase comprising a hydrophobic organic means for floating selected from hydrogenated mono-, di- or tri-glycerides in which from about 70 to 90% by weight of the ester is a 12-hydroxysteric ester and about 10 to 30% by weight of ester is a stearic acid ester, a hydroxylated polyalkene having a molecular weight between about 950 and 10,000, and a non-ionic emulsifier.
A solid pharmaceutical preparation comprising an internal phase and a solid external phase,
- a) the internal phase being a powder mixture comprising discrete solid granules of an antacid means for neutralizing acid and a pharmaceutically acceptable excipient,
- b) the internal phase being surrounded by a solid external phase consisting essentially of a hydrophobic organic means for floating selected from the group consisting of hydrogenated mono-, di- or tri-glycerides, wherein about 70 to 90% by weight of ester is a 12-hydroxysteric ester and about 10 to 30% by weight of ester is a stearic acid ester, a hydroxylated polyalkene having a molecular weight between about 950 and 10,000, and a non-ionic emulsifier comprising a polyoxyethylene-sorbitan mono-ester of an oleic, lauric, stearic or palmitic acid.
A solid pharmaceutical preparation comprising an internal phase and a solid external phase,
- a) the internal phase being a powder mixture of discrete solid granules of an antacid means for neutralizing acid selected from the group consisting of aluminum magnesium hydroxycarbonates and sulphates and a pharmaceutically acceptable excipient,
- b) the internal phase being surrounded by a solid external phase consisting essentially of a hydrophobic organic means for floating selected from hydrogenated mono-, di- or tri-glycerides, in which from about 70 to 90% by weight of the ester is a 12-hydroxystearic ester and about 10 to 30% by weight of ester is a stearic acid ester, a hydroxylated polyalkene having a molecular weight between about 950 and 10,000, and a non-ionic emulsifier.
Dependencies are inferred from the claim text.