Sterodial liposomes
AssigneeThe Liposome Company, Inc.
InventorsAndrew S. Janoff, Mircea C. Popescu, Alan L. Weiner, Lois E. Bolcsak, Paul A. Tremblay, Christine E. Swenson
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Abstract
Methods and compositions are described for the preparation of bioactive agents entrapped in lipid vesicles the bilayers of which comprise a salt form of an organic acid derivative of a sterol, such as the tris-salt form of a sterol hemisuccinate, and to compositions comprising a mixture of tris(hydroxymethyl)aminomethane salt of cholesteryl hemisuccinate with either an antifungal compound or a peptide. These compositions have various applications in vivo.
Claims9
Steroidal liposomes having bilayers consisting essentially of a salt form of cholesteryl hemisuccinate.
A composition comprising completely closed bilayers comprising a salt form of a cholesteryl hemisuccinate and an antifungal compound.
Dependencies are inferred from the claim text.