Radiopharmaceutical product more particularly having a cardiac tropism incorporating a nitride complex of a transition metal and its preparation process

A kit for the preparation of a radiopharmaceutical product, comprising a first bottle containing a phosphine, a second bottle containing sodium nitride, dithiocarbazic acid or a derivative thereof and a third bottle containing a compound having the formula:

• ##STR28## in which V and W, which can be same or different, represent O, S or Se, n and m, which can be the same or different, are equal to 0 or to 1, Y represents N, P or As, and R.sup.1 and R.sup.2, which can be the same or different, represent a straight or branched alkyl radical with 1 to 10 carbon atoms, which is either not substituted or substituted by --O--R.sup.3, OOC--R.sup.3, OCNR.sup.4 R.sup.5 or --NR.sup.4 R.sup.5 groups, in which R.sup.3 is a straight or branched alkyl radical with 1 to 5 carbon atoms and R.sup.4 and R.sup.5, which can be the same or different, are hydrogen atoms or straight or branched alkyl radicals with 1 to 5 carbon atoms, or in which R.sup.1 and R.sup.2 together form a hydrocarbon ring optionally containing 1 or more heteroatoms, R.sup.6 is an alkali metal ion, H.sup.+ or NH.sub.4.sup.+ and p is equal to 0 or an integer between 1 and 5.

A method of diagnosis or therapy for heart conditions, comprising administering to a patient in need thereof an effective amount of a radiopharmaceutical product comprising a complex of a transition metal having the formula:

• (M.ident.N) L.sup.1 L.sup.2
• in which M is a transition metal and L.sup.1 and L.sup.2, which can be the same or different, have the formula:
• ##STR29## in which V and W, which can be the same or different, represent O, S or Se, n and m, which can be the same or different, are equal to 0 or to 1, Y represents N, P or As, and R.sup.1 and R.sup.2, which can be the same or different, represent a straight or branched alkyl radial with 1 to 10 carbon atoms, which is either not substituted or substituted by --O--R.sup.3, OOC--R.sup.3, OCNR.sup.4 R.sup.5 or --NR.sup.4 R.sup.5 groups, in which R.sup.3 is a straight or branched alkyl radical with 1 to 5 carbon atoms and R.sup.4 and R.sup.5, which can be the same or different, are hydrogen atoms or straight or branched alkyl radicals with 1 to 5 carbon atoms, or in which R.sup.1 and R.sup.2 together form a hydrocarbon ring optionally containing one or more heteroatoms.

A method of diagnosis or therapy for heart conditions, comprising administering to a patient in need thereof an effective amount of a radiopharmaceutical product comprising a complex of a transition metal having the formula:

• (M.ident.N) L.sup.1 L.sup.2
• in which M is a transition metal and L.sup.1 and L.sup.2, which can be the same or different, have the formula:
• ##STR30## in which V and W, which can be the same or different, represent O, S or Se, n and m, which can be the same or different, are equal to 0 or to 1, Y represents N, P or As, and R.sup.1 and R.sup.2, which can be the same or different, represent a straight or branched alkyl radial with 1 to 10 carbon atoms, which is either not substituted or substituted by --O--R.sup.3, OOC--R.sup.3, OCNR.sup.4 R.sup.5 or --NR.sup.4 R.sup.5 groups, in which R.sup.3 is a straight or branched alkyl radical with 1 to 5 carbon atoms and R.sup.4 and R.sup.5, which can be the same or different, are hydrogen atoms or straight or branched alkyl radicals with 1 to 5 carbon atoms, or in which R.sup.1 and R.sup.2 together form a hydrocarbon ring optionally containing one or more heteroatoms, wherein R.sup.1 and R.sup.2 are not both unsubstituted alkyl radicals when n and m are equal to 0.