Supercritical fluid and near critical gas extraction of organic solvents from formed articles
AssigneeCiba-Geigy Corporation
InventorsLawrence B. Heit, James M. Clevenger
Life of this patent
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Abstract
Disclosed is a method of removing residual organic solvents from formed compressed articles such as tablets comprised of subjecting the organic solvent laden compressed article to a supercritical fluid or near critical gas whereby residual solvent is transferred from the solvent laden solid article to the supercritical fluid or near critical gas and separating the residual solvent depleted compressed article from the solvent enriched supercritical fluid or near critical gas.
Claims20
A process for extracting residual solvent from a solid article selected from the group consisting of capsules and film coated tablets, said process consisting of exposing that solid article to an inert phase of a fluid under supercritical conditions, transferring a portion of the residual solvent from the solid article to the inert phase of the fluid and removing the inert phase enriched with solvent from the solid article depleted of solvent, wherein said film coated tablets have a film coating comprising a film-forming member selected from the group consisting of cellulose ethers, cellulose esters, gelatin, pharmaceutical glaze, polyethylene glycol, polyvinyl acetate phthalate, sucrose, carnauba wax, microcrystalline wax, (meth)acrylic acid/(meth)acrylic ester copolymers, and other vinylic polymers and copolymers.
A process for extracting residual solvent from a solid article selected from the group consisting of capsules and film coated tablets, said process comprising exposing that solid article to an inert phase of a fluid under supercritical conditions, transferring a portion of the residual solvent from the solid article to the inert phase of the fluid and removing the inert phase enriched with solvent from the solid article depleted of solvent, wherein said film coated tablets have a film coating comprising a film-forming member selected from the group consisting of cellulose ethers, cellulose esters, gelatin, pharmaceutical glaze, polyethylene glycol, polyvinyl acetate phthalate, sucrose, carnauba wax, microcrystalline wax, (meth)acrylic acid/(meth)acrylic ester copolymers and other vinylic polymers and copolymers.
A process for extracting residual solvent from a solid article selected from the group consisting of capsules and film coated tablets, said process consisting of exposing that solid article to an inert phase of a gas under near-critical conditions, transferring a portion of the residual solvent from the solid article to the inert phase of the gas and removing the inert phase enriched with solvent from the solid article depleted of solvent, wherein said film coated tablets have a film coating comprising a film-forming member selected from the group consisting of cellulose ethers, cellulose esters, gelatin, pharmaceutical glaze, polyethylene glycol, polyvinyl acetate phthalate, sucrose, carnauba wax, microcrystalline wax, (meth)acrylic acid/(meth)acrylic ester copolymers, and other vinylic polymers and copolymers.
A process for extracting residual solvent from a solid article selected from the group consisting of capsules and film coated tablets, said process comprising exposing that solid article to an inert phase of a gas under near-critical conditions, transferring a portion of the residual solvent from the solid article to the inert phase of the gas and removing the inert phase enriched with solvent from the solid article depleted of solvent, wherein said film coated tablets have a film coating comprising a film-forming member selected from the group consisting of cellulose ethers, cellulose esters, gelatin, pharmaceutical glaze, polyethylene glycol, polyvinyl acetate phthalate, sucrose, carnauba wax, microcrystalline wax, (meth)acrylic acid/(meth)acrylic ester copolymers, and other vinylic polymers and copolymers.
Dependencies are inferred from the claim text.