Inhibitors for replication of retroviruses and for the expression of oncogene products
AssigneeThe United States of America as represented by the Department of Health and Human Services
InventorsJack S. Cohen, Len Neckers, Cy Stein, She L. Loke, Kazuo Shinozuka
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Abstract
Phosphorothioate oligodeoxyribonucleotide analogs can be used to prevent replication of foreign nucleic acids in the presence of normal living cells, as well as to inhibit the proliferation of neoplastic cells.
Claims20
A compound for inhibiting the expression of an oncogene in a host, the compound comprising a mixed linkage oligonucleotide phosphorothioate having a complementary base sequence with a portion of the oncogene.
A composition for inhibiting the expression of an oncogene in a host, the composition comprising a pharmaceutically acceptable carrier and an effective amount of a mixed linkage oligonucleotide phosphorothioate having a complementary base sequence with a portion of the oncogene.
A method for inhibiting the expression of an oncogene in a host comprising administering to the host an effective amount of a compound comprising a mixed linkage oligonucleotide phosphorothioate having a complementary base sequence with a portion of the oncogene.
Dependencies are inferred from the claim text.