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US 5,284,831 AGranted
Drug delivery porphyrin compositions and methods
AssigneeThe Regents of the University of California
InventorsStephen B. Kahl, Myoung-Seo Koo
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Abstract
The abstract isn’t available for this document.
Claims12
A composition, useful for delivery of boron atoms to cells, comprising:
- a substantially non-toxic porphyrin compound having the structure ##STR14## where R.sup.3 is a closo-carborane and R.sup.2 is an alkyl or an aryl having 1 to about 7 carbon atoms;
- and
- at least one lipoprotein with which the porphyrin compound is complexed.
A method of preparing a cellular drug delivery composition comprising:
- providing a porphine precursor compound with substituents on at least two of the pyrrole rings thereof at pyrrole ring positions 2 and 4, the substituents including a glycol with two hydroxyl groups;
- and,
- contacting the precursor compound with at least two equivalents of an acid chloride having the structure ##STR15## wherein R.sup.3 is a closo-carborane, the contacting conducted in the presence of a reaction rate enhancing amount of p-dimethylamino pyridine, to acylate at least one hydroxyl group of each bis-glycol sustituent and to form a porphine reaction product having at least one R.sup.3 group covalently bonded to each of the pyrrole rings at positions 2 and 4.
Dependencies are inferred from the claim text.