Peptide compound and its preparation

Abstract

Novel peptides of the formula (I") ##STR1## in which R.sup.1 is hydrogen or acyl, R.sup.2.sub.c is lower alkyl, R.sup.3.sub.c is optionally N-substituted indolylmethyl, R.sup.4 is hydrogen, lower alkyl, C.sub.6-10 ar(lower)alkyl, amino(lower)alkyl, protected amino (lower)alkyl, carboxy(lower)alkyl, protected carboxy(lower)alkyl or optionally substituted heterocyclic (lower)alkyl, R.sup.5 is carboxy, protected carboxy, carboxy(lower)alkyl or protected carboxy(lower)alkyl, R.sup.7 is hydrogen or lower alkyl, and A is --O--, --NH--, lower alkylamino or lower alkylene, or a pharmaceutically acceptable salt thereof are disclosed. Additionally, the preparation of such peptides is described. The peptides are used to treat endothelin mediated diseases such as hypertension.

Dependencies are inferred from the claim text.