Pulmonary administration of granulocyte colony stimulating factor
AssigneeAmgen Inc.
InventorsRobert M. Platz, Mark A. Winters, Colin G. Pitt
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Abstract
Granulocyte-colony stimulating factor (G-CSF) can be delivered systemically in therapeutically or prophylactically effective amounts by pulmonary administration using a variety of pulmonary delivery devices, including nebulizers, metered dose inhalers and powder inhalers. Aerosol administration in accordance with this invention results in significant elevation of the neutrophil levels that compares favorably with delivery by subcutaneous injection. G-CSF can be administered in this manner to medically treat neutropenia, as well as to combat or prevent infections.
Claims21
A method for the pulmonary administration of G-CSF to a mammal, comprising directing a neutrophil stimulating amount of G-CSF into the oral cavity of the mammal while the mammal is inhaling for those is need thereof.
Dependencies are inferred from the claim text.