Swollen demineralized bone particles, flowable osteogenic composition containing same and use of the composition in the repair of osseous defects
AssigneeOsteotech, Inc.
InventorsSimon Bogdansky, Robert K. O'Leary
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Abstract
Swollen demineralized bone particles are formulated into a flowable osteogenic composition which is useful in the repair of osseous defects.
Claims18
A flowable osteogenic composition which comprises from about 5 to about 90 weight percent swollen demineralized autogenous or allogenic bone particles exhibiting an average increase in volume and/or weight of at least about 10 percent following contact of the unswollen demineralized bone particles with a demineralized bone particle swelling agent and from about 10 to about 95 weight percent of a biocompatible fluid carrier selected from a member of the group consisting of liquid polyhydroxy compound, liquid ester of a polyhydroxy compound, liquid solution of a solid polyhydroxy compound, liquid solution of a solid ester of a polyhydroxy compound and mixtures thereof,
- wherein the polyhydroxy compound is selected from the group consisting of acyclic polyhydric alcohols, polyalkylene glycols, non-reducing sugars, sugar alcohols, sugar acids, monosaccharides, disaccharides, water-soluble or water dispersible oligosaccharides, polysaccharides and mixtures thereof.
The composition of claim 10 wherein the carrier is dextran.
A flowable osteogenic composition which comprises from about 5 to about 90 weight percent swollen demineralized autogenous or allogenic bone particles exhibiting an average increase in volume and/or weight of at least about 10 percent following contact of the unswollen demineralized bone particles with a demineralized bone particle swelling agent and from about 10 to about 95 weight percent of a biocompatible fluid carrier selected from a member of the group consisting of liquid polyhydroxy compound, liquid ester of a polyhydroxy compound, liquid solution of a solid polyhydroxy compound, liquid solution of a solid ester of a polyhydroxy compound and mixtures thereof,
- wherein the polyhydroxy compound is selected from the group consisting of ethylene glycol, diethylene glycol, triethylene glycol, 1,2-propanediol, glycerol, trimethylolethane, trimethylopropane, erythritol, pentaerythritol, polyethylene glycols, polyvinylalcohols, xylitol, sorbitol, mannitol, dulcitol, arabinose, xylose, ribose, adonitol, arabitol, rhamose, inositol, fructose, galactose, glucose, mannose, sorbose, sucrose, dextrose, maltose, lactose, maltitol, lactitol, stachyose, maltopentaose, eyclomaltohexaose, carrageenan, agar, dextran, alginic acid, guar gum, gum tragacanth, locust bean gum, gum arabic, xanthan gum, amylose and mixtures thereof.
A flowable osteogenic composition which comprises from about 5 to about 90 weight percent swollen demineralized autogenous or allogenic bone particles exhibiting an average increase in volume and/or weight of at least about 10 percent following contact of the unswollen demineralized bone particles with a demineralized bone particle swelling agent and from about 10 to about 95 weight percent of a biocompatible fluid carrier selected from a member of the group consisting of liquid polyhydroxy compound, liquid ester of a polyhydroxy compound, liquid solution of a solid polyhydroxy compound, liquid solution of a solid ester of a polyhydroxy compound and mixtures thereof,
- wherein the carrier is a fatty acid monoester dissolved in a solvent selected from the group consisting of propylene glycol, glycerol, monoacetin, diacetin, liquid polyethylene glycol and mixtures thereof.
Dependencies are inferred from the claim text.