Acrylic copolymer membranes for biosensors
AssigneeEli Lilly and Company
InventorsDouglas J. Allen, Robert S. Nevin
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Abstract
Homogeneous membranes are disclosed which are composed of acrylic copolymers and are capable of absorbing 10% to 50% of their dry weight of water. The copolymers include a hydrophilic component which comprises acrylic esters having a poly(ethylene oxide) substituent as part of the alcohol moiety. The copolymers further comprise methacrylate and/or acrylate monomer units. The membranes are useful in the fabrication of biosensors, e.g., a glucose sensor, intended for in vivo use. Variations in the ratios of the monomeric components make possible the fabrication of membranes which have varying permeabilities.
Claims15
In an implatable device for determining the level of an anlyte in a body, said device comprising a biosensor having sensor elements for evaluating the presence of the analyte and including a membrane enclosing the sensor elements, said membrane providing biocompatibility, protection of the sensor elements from the surrounding biological environment, and control of diffusion of materials to the sensor elements, the improvement comprising forming said membrane from an acrylic copolymer comprising first monomer units consisting of an acrylic ester having methoxy poly(ethylene oxide) methacrylate as part of the alcohol moiety, and second monomer units selected from methacrylates, acrylates and combinations thereof, said membrane absorbing water in an amount of about 10% to about 50% of the dry weight of said membrane.
Dependencies are inferred from the claim text.