Pharmacologically active compounds, methods for the preparation thereof and compositions containing the same
AssigneeOrion-yhtyma Oy
InventorsReijo J. Backstrom, Kalevi E. Heinola, Erkki J. Honkanen, Seppo K. Kaakkola, Pekka J. Kairisalo, Inge-Britt Y. Linden, Pekka I. Mannisto, Erkki A. O. Nissinen, Pentti Pohto, Aino K. Pippuri, Jarmo J. Pystynen
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Abstract
Catechol compounds of formula I ##STR1## where R.sub.1, R.sub.2, R.sub.3 and X are as described herein are effective Catechol-O-methyltransferase inhibitors.
Claims3
A compound according to formula I ##STR52## wherein R.sub.1 and R.sub.2 independently represent hydrogen, carbamoyl which is substituted by an alkyl of 1 to 4 carbon atoms, alkylcarbonyl of 2 to 5 carbon atoms or phenyl carbonyl, X represents halogen nitro or cyano and R.sub.3 represents ##STR53## wherein R.sub.4 represents cyano or alkylcarbonyl of 2 to 5 carbon atoms and R.sub.5 represents cyano, alkylcarbonyl of 2 to 5 carbon atoms, or alkoxycarbonyl of 2 to 9 carbon atoms, or pharmaceutically acceptable salts thereof.
Dependencies are inferred from the claim text.