Intermediates for conjugation of polypeptides with high molecular weight polyalkylene glycols
AssigneeDDI Pharmaceuticals, Inc.
InventorsMark Saifer, Ralph Somack, L. David Williams
Life of this patent
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Abstract
A biologically persistent, water-soluble, substantially non-immunogenic, substantially non-antigenic conjugate of superoxide dismutase is prepared by coupling one to five strands of a polyalkylene glycol which is polyethylene glycol or polyethylene-polypropylene glycol copolymer, wherein said polyalkylene glycol has an average molecular weight of about 35,000-1,000,000.
Claims1
A polyalkylene glycol which is a polyethylene glycol or polyethylene-polypropylene glycol copolymer wherein all of the polyalkylene glycol has an average molecular weight as determined by HPLC using PEG as standard of about 35,000-200,000 and is unsubstituted or substituted at one terminal by a C.sub.1-4 alkyl group and substituted at another terminal by a group of the formula:
- ##STR2##
Dependencies are inferred from the claim text.