Methods for inhibiting rejection of transplanted tissue
AssigneeThe General Hospital Corporation
InventorDenise Faustman
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Abstract
A method for inhibiting rejection by a recipient animal of a transplanted tissue, said method comprising modifying, eliminating, or masking an antigen which, when present on the surface of a cell of said tissue, is capable of causing a T-lymphocyte-mediated response in said animal, to inhibit antigen-mediated interaction between said cell and a T-lymphocyte of said animal without causing lysis of said cell.
Claims20
A method for inhibiting rejection by a recipient animal of a human non-lymphoid tissue which is to be transplanted into a recipient animal, said method comprising modifying, eliminating, or masking an antigen of said non-lymphoid tissue which, when present on the surface of a cell of said human tissue, is capable of causing a T-lymphocyte-mediated response in the recipient animal, to inhibit antigen-mediated interaction between said cell and a T-lymphocyte of the recipient animal without causing lysis of said cell.
A method for inhibiting rejection by a recipient animal of a non-lymphoid tissue obtained from an animal of a different species which is to be transplanted into the recipient animal, said method comprising modifying, eliminating, or masking an antigen of said non-lymphoid tissue which, when present on the surface of a cell of said tissue, is capable of causing a T-lymphocyte-mediated response in the recipient animal, to inhibit antigen-mediated interaction between said cell and a T-lymphocyte of the recipient animal without causing lysis of said cell.
Dependencies are inferred from the claim text.