Graft for promoting autogenous tissue growth
AssigneePurdue Research Foundation
InventorsStephen F. Badylak, Leslie A. Geddes, K. Donald Shelbourne, Gary C. Lantz, Arthur C. Coffey
Life of this patent
Estimating the term…
Abstract
Surgical repair of diseased or damaged endogenous connective tissue can be accomplished using a tissue graft formed from a delaminated segment of intestinal tissue. The tissue graft comprises the intestinal tunica submucosa, muscularis mucosa and stratum compactum delaminated from the tunica muscularis and the luminal portion of the tunica mucosa. The graft can be conditioned by stretching and formed as a multilayer composition for high tensile strength and resistance to tearing at its points of attachment to existing physiological structures.
Claims13
A tendon or ligament graft construct for use as connective tissue substitute, said graft formed from a segment of intestinal tissue of a warm-blooded vertebrate, said segment comprising the tunica submucosa, the muscularis mucosa, and the stratum compactum of the tunica mucosa, said tunica submucosa, muscularis mucosa and stratum compactum being delaminated from the tunica muscularis and the luminal portion of the tunica mucosa of said segment of intestinal tissue, said graft construct having an intermediate portion and opposite end portions, said end portions being formed to present multiple segment layers for providing reinforcement for attachment of the graft construct to existing physiological structures, said graft construct further being conditioned for its use as a connective tissue substitute by stretching so that the graft construct is longer than the segment of intestinal tissue from which it is formed.
A tendon or ligament graft for use as a connective tissue substitute in both ligament and tendon locations throughout the body, said graft comprising intestinal tissue of a warm-blooded vertebrate, said segment comprising the tunica submucosa, the muscularis mucosa and the stratum compactum of the tunica mucosa, said tunica submucosa, muscularis muscosa and stratum compactum being delaminated from the tunica muscularis and the luminal portion of the tunica mucosa of said segment of intestinal tissue, said graft being formed to have an intermediate portion comprising multiple tissue segment layers, said intermediate portion terminating with opposite end portions, said end portions being formed for attachment to a bone, tendon or ligament, said graft further being conditioned for use as a tendon or ligament substituted by stretching so that the graft is longer than the segments of intestinal tissue from which it is formed.
A tendon or ligament graft material formed from a segment of intestinal tissue, said graft material comprising the tunica submucosa, the muscularis mucosa and the stratum compactum of the tunica mucosa, said tunica submucosa, muscularis mucosa and stratum compactum being delaminated from the tunica muscularis and the luminal portion of the tunica mucosa of said segment of intestinal tissue, and said graft material initially having a longitudinal dimension corresponding to the length of the segment of intestinal tissue and a lateral dimension proportioned to the diameter of the segment of intestinal tissue, said tissue graft material being stretched longitudinally so that it is longer than the segment of intestinal tissue from which it was formed.
Dependencies are inferred from the claim text.