Recombinant infectious laryngotracheitis virus
OwnerCalvin L. Keeler, Jr.inventor
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Abstract
The present invention is concerned with the preparation of an Infectious Laryngotracheitis Virus (ILTV) mutant which does not produce a functional thymidine kinase enzyme as a result of a mutation in the TK gene, and its preparation. The invention also relates to an ILTV mutant containing a heterologous gene encoding an antigen of an avian pathogen incorporated into the TK gene. Such an ILTV mutant can be applied as a vector vaccine to induce an immune response after infection of an appropriate host animal.
Claims7
An Infectious Laryngotracheitis Virus (ILTV) mutant comprising a mutation in the gene encoding thymidine kinase, wherein the ILTV mutant lacks the ability to produce functional thymidine kinase.
A recombinant DNA vector molecule comprising a portion of the ILTV thymidine kinase gene and flanking DNA required for facilitating homologous recombination between said vector and ILTV genomic DNA.
Dependencies are inferred from the claim text.