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AssigneeAtrix Laboratories, Inc.
InventorsRichard L. Dunn, James P. English, Donald R. Cowsar, David D. Vanderbilt
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A biodegradable polymer is provided for use in providing syringeable, in-situ forming, solid biodegradable implants for animals. The polymer is placed into the animal in liquid form and cures to form the implant in-situ. A thermoplastic system to form said implant comprises the steps of dissolving a non-reactive polymer in biocompatible solvent to form a liquid, placing the liquid within the animal, and allowing the solvent to dissipate to produce the implant. An alternative, thermosetting system comprises mixing together effective amounts of a liquid acrylic ester terminated, biodegradable prepolymer and a curing agent, placing the liquid mixture within an animal and allowing the prepolymer to cure to form the implant. Both systems provide a syringeable, solid biodegradable delivery system by the addition of an effective level of biologically active agent to the liquid before injection into the body.
A pharmaceutical composition for forming a biodegradable pharmaceutically acceptable implant in-situ within a living body, comprising an effective amount of a pharmaceutically acceptable liquid acrylic-ester terminated prepolymer of terminal acryloyl groups and a residue of an oligomer having terminal functional groups capable of reacting with acryloyl acylating groups wherein the prepolymer is capable of being cured into said implant in-situ within a living body and the cured form of the prepolymer is water insoluble and is biodegradable by simple or enzymatically antalyzed hydrolysis;
A pharmaceutical kit suitable for in-situ formation of a biodegradable implant in a body, which comprises:
Dependencies are inferred from the claim text.