Treatment of aluimmunization and refractoriness to platelet transfusion by protein A column therapy
AssigneeRegents of the University of Minnesota
InventorsDouglas J. Christie, Robert B. Howe
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Abstract
The invention provides a therapeutic method for treating refractoriness to platelet transfusion by isolating blood serum from an alloimmunized patient undergoing platelet transfusion therapy, passing the serum through a bed comprising staphococcal protein A coupled to a solid support and returning the treated plasma to the patient. The method can be conducted by batch-type procedure or by continuously conducting the steps so that blood is withdrawn, passed through the bed, and returned to the patient as a continuous stream. The method is useful to treat alloimmunized patients suffering from leukemia, aplastic anemia, myelofibrosis, myelodysplastic syndrome, or in a bone marrow transplant patient.
Claims7
A therapeutic method for treating refractoriness to platelet transfusion due to alloimmunization, comprising:
- (a) isolating a portion of blood serum from an alloimmunized patient undergoing platelet transfusion therapy;
- (b) passing the portion of serum through a bed comprising Staphylococcal protein A coupled to a finely divided solid support, so that IgG and IgG-associated immune complexes are removed from the serum, to yield a portion of treated plasma;
- and
- (c) returning said portion of treated plasma to said patient to achieved an increase in average daily platelet counts over pretreatment levels for at least one week posttransfusion.
Dependencies are inferred from the claim text.