Phosphorus-containing squalene synthetase inhibitors and method

A compound having the structure ##STR154## wherein m is 0, 1, 2 or 3;

• n is 0, 1, 2, 3 or 4;
• Y.sup.1 and Y.sup.2 are H or halogen;
• R.sup.2, R.sup.3 and R.sup.4 may be the same or different and are independently H, metal ion, C.sub.1 to C.sub.8 alkyl or C.sub.3 to C.sub.12 alkenyl;
• X is NH or --NCH.sub.2 R.sup.15 wherein R.sup.15 is H or C.sub.1 to C.sub.5 alkyl;
• and
• R.sup.1 is R.sup.5 -Q.sup.1 -Q.sup.2 -Q.sup.3 -wherein Q.sup.1, Q.sup.2 and Q.sup.3 are the same or different and are independently ##STR155## or a single bond, with the proviso that if Q.sup.1 is a bond, the Q.sup.2 and Q.sup.3 are bonds, and if Q.sup.2 is a bond than Q.sup.3 is a bond, and wherein R.sup.6 is H, lower alkyl, halo or haloalkyl;
• R.sup.7 is H, halogen, lower alkyl or lower alkylthio;
• R.sup.8 is H, halogen trimethylsilyl or lower alkyl;
• and R.sup.9 is H or lower alkyl;
• ##STR156## CH.sub.3 (CH.sub.2).sub.p where p is an integer form 2 to 7, or R.sup.16 --C.tbd.C--CH.sub.2 --where R.sup.16 is H or lower alkyl;
• R.sup.10, and R.sup.11 are the same of different and are independently H, lower alkyl, haloalkyl, halogen or lower alkenyl or R.sup.10 and R.sup.11 can be taken together to form (CH.sub.2).sub.s where s is an integer from 2 to 7;
• R.sup.12 is H, lower alkyl;, halogen or lower alkenyl;
• and R.sup.13 and R.sup.14 are the same or different and are independently lower alkyl;
• with the proviso that if all of Q.sup.1, Q.sup.2 and Q.sup.3 are bonds, the both R.sup.10 and R.sup.11 cannot be H, and R.sup.5 cannot be CH.sub.3 (CH.sub.2).sub.p -- with a p less than or equal to 4, and including all stereoisomers thereof.