Method for the stabilization of methionine-containing polypeptides
AssigneeChiron Ophthalmics, Inc.
InventorHarun Takruri
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Abstract
A method for inhibiting the oxidation of a polypeptide in a liquid or semi-solid pharmaceutical or therapeutic preparation, the polypeptides having an amino acid sequence comprising at least one methionine residue, wherein the amino acid methionine is added in a sufficient amount to inhibit the oxidation of the methionine residue(s) to methionine sulfoxide.
Claims25
A method of inhibiting oxidation of a liquid or semi-liquid composition of a polypeptide having an amino acid sequence comprising at least one methionine residue which comprises adding methionine to the composition in an amount sufficient to inhibit oxidation of the at least one methionine residue, said amount being between about 0.01% w/v and 0.3% w/v.
A stable liquid or semi-solid pharmaceutical or therapeutic preparation which comprises a polypeptide having an amino acid sequence which compiles at least one methionine residue and methionine, wherein the methionine is present at a concentration sufficient to inhibit oxidation of the at least one methionine residue of the polypeptide, said concentration being between about 0.01% w/v and 0.3% w/v.
A method of stabilizing an aqueous-based tissue storage medium which comprises a tissue growth factor having an amino acid sequence comprising at least one methionine residue which comprises adding methionine to the medium in an amount sufficient to inhibit oxidation of the at least one methionine residue, said amount being between about 0.01% w/v and 0.3% w/v.
Dependencies are inferred from the claim text.