Human mannose-binding protein
AssigneeChildren's Medical Center Corporation
InventorRaymond A. B. Ezekowitz
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Abstract
Purified human mannose-binding protein and fragments thereof, nucleic acid producing these fragments, and vectors and cells including such nucleic acid are disclosed. The peptides and antibodies to those peptides are useful for diagnosis and treatment of disease.
Claims13
An isolated nucleic acid encoding human mannose-binding protein, said human mannose-binding protein having the sequence encoded by plasmid pMBP deposited in the ATCC as strain number ATCC 67483.
An isolated nucleic acid comprising a nucleic acid sequence encoding a polypeptide, said polypeptide comprising at least 20 contiguous amino acids of the carbohydrate binding domain of the human mannose-binding protein encoded by plasmid pMBP deposited in the ATCC as strain number ATCC 67483, said polypeptide being characterized by the ability to bind specifically to cells expressing mannose, N-acetylglucosamine, or fucose.
An isolated nucleic acid comprising a nucleic acid sequence encoding a polypeptide, said polypeptide comprising at least 20 contiguous amino acids of the complement fixing domain of the human mannose-binding protein encoded by plasmid pMBP deposited in the ATCC as strain number ATCC 67483, said polypeptide being characterized by the ability to fix complement.
Dependencies are inferred from the claim text.