Increasing blood-brain barrier permeability with permeabilizer peptides
AssigneeAlkermes, Inc.
InventorsJohn W. Kozarich, Gary F. Musso, Bernard Malfroy-Camine
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Abstract
Polypeptides called receptor mediated permeabilizers (RMP) increase the permeability of the blood-brain barrier to molecules such as therapeutic agents or diagnostic agents. These receptor mediated permeabilizers are more efficacious than bradykinin in causing the blood-brain barrier to become more permeable. The permeabilizer A-7 or conformational analogues can be intravenously co-administered to a host together with molecules whose desired destination is the cerebrospinal fluid compartment of the brain. The permeabilizer A-7 or conformational analogues allow these molecules to penetrate the blood-brain barrier and arrive at this destination.
Claims7
A method for increasing the permeability of the blood-brain barrier of a host to a molecule present in the bloodstream of the host comprising the intravascular administration of an effective amount of a blood-brain barrier permeabilizer comprising a peptide with the amino acid sequence of NH.sub.2 -arginine-proline-hydroxyproxyproline-glycine-thienylalanine-serine-prolin e-4-Me-tyrosine.PSI.(CH.sub.2 NH) arginine-COOH (Seq. ID NO. 1) or a conformational analogue thereof.
Dependencies are inferred from the claim text.