Myoinsitol derivatives, process for preparing same, phosphorylating agent, and its utilization
AssigneeMitsui Toatsu Chemicals, Inc.
InventorsShoichiro Ozaki, Yutaka Watanabe
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Abstract
A process for preparing myoinositol polyphosphoric acid from myoinositol via a polyacylmyoinositol, a process for preparing a polysilyl-polyacylmyoinositol from a polyacylmyoinositol, and a process for preparing an optically active myoinositol polyphosphoric acid from the above product or a polysilylmyoinositol.
Claims5
A compound selected from the group consisting of 1,3,4,5,6-pentaacylmyoinositol, 1,3,4,5-tetraacylmyoinositol, 1,3,5-triacylmyoinositol, 1,4,5-triacylmyoinositol, 1,3,4-triacylmyoinositol, 1,5,6-triacylmyoinositol or 1',5-diacylmyoinositol.
A compound selected from the group consisting of 2,6-bis(dimethyl-t-butylsilyl)-1,3,4,5-tetrabenzoylmyoinositol, 2,6-bis(triethylsilyl)-1,3,4,5-tetrabenzoylmyoinositol, polysilylmyoinositol or 2,6-bis(dimethyl-t-butyl)-3-benzoylmyoinositol.
A compound in which the hydroxyl group of myoinositol or its derivative is bonded to the carboxyl group of 2,3-O-alkylidene tartaric acid monoester or 2,3-O-silylidene tartaric acid monoester by an ester bond.
A process for preparing myoinositol polyphosphoric acid from polyacyl myoinositol which process comprises the steps of:
- (a) protecting the non-acylated hydroxy radical of polyacyl myoinositol with a protecting group removable by hydrogen reduction or with a silylating agent;
- (b) de-acylating the protected polyacyl myoinositol;
- (c) phosphorylating the thus formed hydroxyl group with a phosphorylating agent;
- and thereafter
- (d) reducing the phosphorylating agent with hydrogen or catalytically reducing the phosphorylating agent with palladium to form myoinositol polyphosphoric acid.
Dependencies are inferred from the claim text.