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US 5,264,586 AGranted
Analogs of calicheamicin gamma1I, method of making and using the same
AssigneeThe Scripps Research Institute
InventorsKyriacos C. Nicolaou, Adrian L. Smith, Chan-Kou Hwang, Emmanuel Pitsinos
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Abstract
Chimeric analogs of calicheamicin that include an analog of calicheamicinone linked to an ester or glycoside, (-)-calicheamicinone and its analogs are disclosed.
Claims6
A compound whose structure corresponds to the formula ##STR23## R.sup.1 and R.sup.2 together form a moiety selected from the group consisting of ##STR24## Y is methyl or benzyl;
- SiR.sub.3 contains three R groups that are the same or different and are C.sub.1 -C.sub.6 alkyl or phenyl.
A compound whose structure corresponds to the formula ##STR25## R.sup.1 and R.sup.2 together form a moiety selected from the group consisting of ##STR26## Y is methyl or benzyl;
- and SiR.sub.3 contains three R groups that are the same or different and are C.sub.1 -C.sub.6 alkyl and phenyl.
Dependencies are inferred from the claim text.