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US 5,264,570 AGranted
Method for making 2-[.sup.18 F]fluoro-2-deoxy-D-glucose
AssigneeGeneral Electric Company
InventorsBruce F. Johnson, Donald H. Maylotte, Cheryl L. Sabourin
Life of this patent
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Abstract
A method is provided for synthesizing 2-fluoro-2-deoxy-D-glucose having an [.sup.18 F] fluoride ion employing a dibenzo substituted aminopolyether (Kryptofix 222BB) as a phase-transfer reagent.
Claims3
A method for making 2-[.sup.18 F]fluoro-2-deoxy-D-glucose which comprises,
- (1) contacting at a temperature of 40.degree. C. to 100.degree. C., 1,3,4,6-tetra-O-acetyl-2-0-trifluoromethanesulfonyl-2-deoxy-.beta.-D-manno pyranose and [.sup.18 F]fluoride ion in the presence of an inert organic solvent and the phase-transfer having the formula, ##STR4## (2) effecting the substantial removal of the organic solvent, (3) heating the resulting mixture of (2) in the presence of an aqueous hydrogen halide until deprotection of the resulting acetylated 2-[.sup.18 F]fluoro-2-deoxy-D-glucose is effected, and
- (4) recovering 2-[.sup.18 F]fluoro-2-deoxy-D-glucose from the mixture of (3).
Dependencies are inferred from the claim text.