Inhibitors for replication of retroviruses and for the expression of oncogene products
AssigneeThe United States of America as represented by the Department of Health and Human Services
InventorsJack S. Cohen, Len Neckers, Cy Stein, She L. Loke, Kazuo Shinozuka
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Abstract
Phosphorothioate oligodeoxyribonucleotide analogs can be used to prevent replication of foreign nucleic acids in the presence of normal living cells, as well as to inhibit the proliferation of neoplastic cells.
Claims48
A compound capable of inhibiting the replication or cytopathic effect of a foreign nucleic acid in a host, the compound having the formula:
- ##STR3## wherein:
- n is in the range of from 2 to 30, inclusive;
- X is selected from the group consisting of methyl, ethoxy, S and O such that at least one X is S;
- and
- B is selected from the group consisting of adenine, cytosine, guanine, and thymine, such that the compound has a complementary base sequence with a portion of the foreign nucleic acid.
A composition for inhibiting the replication of cytopathic effect of a foreign nucleic acid in a host, the composition comprising a pharmaceutically acceptable carrier and an effective amount of a compound of the formula:
- ##STR4## wherein:
- n is in the range of from 2 to 30, inclusive;
- X is selected from the group consisting of methyl, ethoxy, S and O such that at least one X is S;
- and
- B is selected from the group consisting of adenine, cytosine, guanine, and thymine, such that the compound has a complementary base sequence with a portion of the foreign nucleic acid.
A method for inhibiting the replication or cytopathic effect of a foreign nucleic acid in a host comprising the step of administering to the host an effective amount of a compound of the formula:
- ##STR5## wherein:
- n is in the range of from 2 to 30, inclusive;
- X is selected from the group consisting of methyl, ethoxy, S and O such that at least one X is S;
- and
- B is selected from the group consisting of adenine, cytosine, guanine, and thymine, such that the compound has a complementary base sequence with a portion of the foreign nucleic acid.
A compound capable of inhibiting the replication or cytopathic effect of a foreign nucleic acid in a host, the compound comprising a mixed linkage oligonucleotide phosphorothioate having a complementary base sequence with a portion of the foreign nucleic acid.
A composition for inhibiting the replication or cytopathic effect of a foreign nucleic acid in a host, the composition comprising a pharmaceutically acceptable carrier and an effective amount of a mixed linkage oligonucleotide phosphorothioate having a complementary base sequence with a portion of the foreign nucleic acid.
A method for inhibiting the replication or cytopathic effect of a foreign nucleic acid in a host comprising the step of administering to the host an effective amount of a mixed linkage oligonucleotide phosphorothioate having a complementary base sequence with a portion of the foreign nucleic acid.
Dependencies are inferred from the claim text.