Drug-containing protein-bonded liposome
AssigneeMitsubishi Kasei Corporation
InventorsToshiaki Tagawa, Saiko Hosokawa, Kazuhiro Nagaike
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Abstract
A drug-containing protein-bonded liposome comprising a liposome containing a drug and having maleimide residues on its surface, and a protein and residues of a compound having a polyalkylene glycol moiety, bonded via respective thiol groups to the maleimide residues.
Claims15
A drug containing, protein-bonded liposome, which comprises a liposome containing a drug, said liposome having maleimide groups on the surface thereof, wherein a portion of the maleimide groups are bonded to a thiol group-containing protein and a remaining portion of the maleimide groups are bonded to a thiol group-containing polyethylene glycol moiety;
- said liposome comprising phosphatidyl choline, cholesterol and maleimide-modified phosphatidyl ethanolamine.
An antitumor drug, comprising a liposome containing a drug, said liposome having maleimide groups on the surface thereof, wherein a portion of the maleimide groups are bonded to a thiol group-containing protein and a remaining portion of the maleimide groups are bonded to a thiol group-containing polyethylene glucol moiety;
- said liposome comprising phosphatidyl choline, cholesterol and maleimide-modified phosphatidyl ehtanolamine.
Dependencies are inferred from the claim text.