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AssigneeCardiopulmonics, Inc.
InventorsSuzanne Winters, Kenneth A. Solen, Clifton G. Sanders, J. D. Mortensen, Gaylord Berry
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The present invention is directed to multifunctional thrombo-resistant coatings for use with biomedical devices and implants, such as a coating which includes a siloxane surface onto which a plurality of amine functional groups have been bonded. Covalently bonded to the amine functional groups are a plurality of poly(ethylene oxide) chains, such that a single poly(ethylene oxide) chain is bonded to a single amine functional group. A plurality of different bioactive molecules, designed to counteract specific blood-material incompatibility reactions, are covalently bonded to poly(ethylene oxide) chains, such that a single bioactive molecule is coupled to a single polyethylene oxide chain. The methods of manufacturing the present invention include preparing a material having a siloxane surface onto which a plurality of amine functional groups have been bonded. This is achieved by plasma etching with ammonia gas or by plasma polymerization of a siloxane monomer in the presence of ammonia gas. The amine-containing siloxane surface is reacted with poly(ethylene oxide) chains terminated with functional groups capable of reacting with the amine groups on the siloxane surface. The material is then reacted with a plurality of different bioactive molecules which counteract the specific blood-material incompatibility reactions, such that a single bioactive molecule is coupled to a single poly(ethylene oxide) chain. The resulting siloxane surface contains a plurality of different bioactive molecules capable of reacting with blood components which come in proximity to the siloxane surface in order to resist blood-material incompatibility reactions.
A multifunctional thrombo-resistant composition for use on surfaces which contact blood comprising a material having a siloxane surface which is permeable to a gas onto which a plurality of at lest two different bioactive molecules are covalently bonded, and further comprising a plurality of poly(ethylene oxide) chains, the at least two different bioactive molecules being covalently bonded to the siloxane surface through the plurality of poly(ethyl oxide) chains such that a single bioactive molecule is correspondingly coupled to a single poly(ethyl oxide) chain which in turn is bonded to the siloxane surface, said bioactive molecules counteracting specific blood-material incompatibility reactions when the blood comes into proximity of the surface of the material without precluding the siloxane surface from being permeable to the gas.
A multifunctional thrombo-resistant composition for use on surfaces which contact load, the composition being made by a process comprising the steps of:
A multifunctional thrombo-resistant composition comprising a plurality of compounds having the formula X--NH--R.sub.1 --(CH.sub.2 CH.sub.2 O).sub.n --R.sub.2 --Y and X--NH--R.sub.1 --(CH.sub.2 CH.sub.2 O).sub.n --R.sub.2 --Z wherein X is a gas permeable siloxane surface;
Dependencies are inferred from the claim text.