Acylamino acid antihypertensives in the treatment of congestive heart failure

A method of treating congestive heart failure comprising administering an effective amount of a compound having the structural formula ##STR61## wherein R.sup.1a is Y--C.sub.6 H.sub.4 --, Y--C.sub.6 H.sub.4 S--, Y--C.sub.6 H.sub.4 O--, ##STR62## .alpha.-naphthyl, .beta.-naphthyl, furyl, benzofuryl, benzothienyl, H.sub.2 N(CH.sub.2).sub.m --, diphenylmethyl or ##STR63## R.sup.2 is alkyl, alkyl--S(O).sub.0-2 (CH.sub.2).sub.k S(O).sub.0-2 (CH.sub.2).sub.q --, alkyl-O(CH.sub.2).sub.q --, R.sup.5 (CH.sub.2).sub.k --O(CH.sub.2).sub.q --, R.sup.5 (CH.sub.2).sub.q --, H.sub.2 N(CH .sub.2).sub.q --, cycloalkyl(CH.sub.2).sub.k --, R.sup.13 CONH(CH.sub.2).sub.q --, R.sup.13 NHCO(CH.sub.2).sub.q -- or R.sup.6 OCO(CH.sub.2).sub.q --;

• R.sup.3 is --OR.sup.7, --NR.sup.7 R.sup.8, ##STR64## R.sup.4 and R.sup.13 are independently hydrogen, alkyl or Y.sup.1 --C.sub.6 H.sub.4 --;
• R.sup.5 is Y.sup.2 --C.sub.6 H.sub.4 13 , Y.sup.2 --C.sub.6 H.sub.4 S--, Y.sup.2 --C.sub.6 H.sub.4 O--, naphthyl, furyl, thienyl, benzofuryl, benzothienyl, indolyl or ##STR65## provided that when R.sup.5 is Y.sup.2 --C.sub.6 H.sub.4 S-- or Y.sup.2 C.sub.6 H.sub.4 O--, k is 2 or 3;
• R.sup.14 is R.sup.5, mono-unsaturated lower alkyl, hydroxy, alkoxy or alkylthio, provided that when R.sup.14 is hydroxy or alkoxy, k is 2 or 3 and when R.sup.14 is mono-unsaturated alkyl or alkylthio, k is 1, 2 or 3;
• R.sup.6, R.sup.7 and R.sup.8 are independently H, alkyl, hydroxyalkyl, dihydroxyalkyl, alkoxyalkyl, dialkoxyalkyl, alkoxyalkoxyalkyl, haloalkyl, (haloalkoxy)alkyl, aminoalkyl, alkylaminoalkyl, dialkylaminoalkyl, arylalkyl or alkyl substituted with a 5-6 membered saturated ring comprising 1-2 oxygen atoms as ring members wherein the ring carbon atoms may be substituted with 0-2 alkyl substituents, or R.sup.7 and R.sup.8 together with the nitrogen to which they are attached complete a 5-7 membered ring, wherein one of the 4-6 ring members comprising R.sup.7 and R.sup.8 may be a nitrogen atom, an alkyl-substituted nitrogen atom or an oxygen atom, and wherein the ring may be substituted on the ring carbon atoms with substituents chosen from alkyl and hydroxy groups;
• R.sup.9 is hydrogen, alkyl, carboxyalkyl, mercaptoalkyl, alkylthioalkyl, aminoalkyl, hydroxyalkyl, phenylalkyl, hydroxyphenylalkyl, guanidinoalkyl, imidazolyalkyl, indolylalkyl, or carbamoylalkyl;
• n is 0-2;
• m and k are independently 0-3;
• q is 1-4;
• X and X.sup.1 are independently a bond, --O--, --S--, or --CH.sub.2 --;
• Q is hydrogen or R.sup.10 CO--;
• R.sup.10 is alkyl, hydroxyalkyl, alkoxyalkyl, alkylaminoalkyl, dialkylaminoalkyl, Y.sup.3 --C.sub.6 H.sub.4 -alkyl, alkoxy, Y.sup.3 --C.sub.6 H.sub.4 --, naphthyl, furyl, thienyl or pyridyl;
• Y, Y.sup.1, Y.sup.2 and Y.sup.3 independently represent one or more substituents selected from H, alkyl, cycloalkyl, alkoxy, OH, F, Cl, Br, CN, --CH.sub.2 NH.sub.2, --CO.sub.2 H, --CO.sub.2 alkyl, --CONH.sub.2 and phenyl;
• or a pharmaceutically acceptable addition salt thereof.