Cyclodextrin polymers and cyclodextrins immobilized on a solid surface
AssigneeThe Trustees of the University of Pennsylvania/Childrens Hospital Corporation
InventorsPaul B. Weisz, Yuen W. Shing
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Abstract
Polyionic derivatives of cyclodextrin polymers and cyclodextrins immobilized on a solid surface are disclosed. Compositions and methods for separating a molecular species, including but not limited to a biologically active protein, from a mixture, for the storage of protein factors and for the therapeutic biodelivery of protein factors which employ the polyionic derivatives of cyclodextrin polymers and cyclodextrins immobilized on a solid surface are also disclosed.
Claims7
A process for the preparation of polysulfated polymer of an alpha-, beta-, or gamma-cyclodextrin which comprises subjecting a solid, water insoluble polymer of an alpha-, beta-, or gamma-cyclodextrine to sulfating conditions until the degree of sulfation is from about 10 to about 16 sulfate groups per cyclodextrin unit of the polymer.
A process for the preparation of polysulfated alpha-, beta-, or gamma-cyclodextrin immobilized on a solid surface which comprises subjecting a solid, water insoluble composition of an alpha-, beta-, or gamma-cyclodextrin immobilized on a solid surface to sulfating conditions until the degree of sulfation is from about 10 to about 16 sulfate groups per immobilized cyclodextrin unit.
Dependencies are inferred from the claim text.