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US 5,262,305 AGranted
Interferant eliminating biosensors
AssigneeE. Heller & Company
InventorsAdam Heller, Ruben Maidan
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Abstract
A biosensor including an interferant-eliminating catalyst and method for analyzing an analyte in a biological sample is disclosed.
Claims20
A biosensor comprising:
- an electrode on which an analyte is electrooxidized at a given applied potential;
- and
- an interferant-eliminating layer substantially covering the electrode but electrically isolated therefrom at the given applied potential, comprising a catalyst which is capable of catalyzing substantial oxidation of a plurality of interferants but not substantial oxidation of the analyte.
A biosensor comprising:
- an electrode on which an analyte is electrooxidized at a given applied potential;
- and
- an interferant-eliminating layer substantially covering the electrode but electrically isolated therefrom, comprising a preactivated, oxidized catalyst which is capable of catalyzing substantial oxidation of a plurality of interferants but not substantial oxidation of the analyte.
A process for producing a preactivated interferant-eliminating biosensor, said process comprising the steps of:
- substantially covering an electrode on which an analyte is electrooxidized with an interferant-eliminating layer comprising a catalyst, said catalyst capable of catalyzing substantial oxidation of a plurality of interferants but not substantial oxidation of the analyte;
- and
- reacting the catalyst with an oxidant to substantially increase the oxidation state of the catalyst and to form a stable, oxidized catalyst intermediate.
A process for producing a preactivated, interferant-eliminating biosensor, said process comprising the steps of:
- substantially covering an enzyme electrode on which an analyte is electrooxidized with an interferant-eliminating layer containing a catalyst, said catalyst capable of catalyzing substantial oxidation of a plurality of interferants but not substantial oxidation of the analyte;
- reacting the catalyst with an oxidant to increase the oxidation state of the catalyst and to form a stable, oxidized catalyst intermediate.
A process for analyzing analyte in the presence of a plurality of interferants in a test sample comprising the steps of:
- contacting a sample with a preactivated, interferant eliminating biosensor having an electrode and an interferant eliminating layer;
- substantially oxidizing interferants in the interferant eliminating layer;
- and
- detecting the analyte at the electrode in the absence of substantial interference.
1 more element
Dependencies are inferred from the claim text.