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US 5,262,166 AGranted
Resorbable bioactive phosphate containing cements
OwnerSung-Tsuen Liu, Harvey H. Chunginventors
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Abstract
A surgical cement of high biocompatibility, useful in orthopedic, maxillofacial and dental applications, comprising a calcium alkali phosphate cement with relatively high surface pH of about 7 or higher, and having a wide variety of chemical compositions, permitting flexibility in controlling the bioresorption rate by changing the chemical composition of the cementing powder.
Claims17
A surgical cement for orthopedic, dental, and maxillofacial applications comprising:
- a cementing powder selected from the group of calcium alkali phosphate ceramics consisting of calcium sodium phosphate or calcium potassium phosphate ceramics;
- a setting reagent selected from the group of acidic citrates consisting of citric acid or acidic citrate salts wherein the weight ratio of cementing powder to setting reagent lies between 1.2:1 and 10:1;
- and
- an effective amount of an aqueous setting solution selected from the group consisting of sterilized pure water and saline water to form a cementitious paste, said paste reaching a neutral pH of 7 shortly after setting.
1 more element
A kit for making a surgical cement for orthopedic, dental, and maxillofacial applications comprising:
- a cementing powder consisting of calcium alkali phosphate ceramics;
- and
- a setting reagent selected from the group of acidic citrates consisting of citric acid or acidic citrate salts,
- said cementing powder and said setting reagent, when admixed with an effective amount of an aqueous solution forms a cementitious paste, which after setting, will attain a pH of at least 7.
1 more element
Dependencies are inferred from the claim text.