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AssigneeThe Biomembrane Institute
InventorsYasuyuki Igarashi, Fugiang Ruan, Yoshito Sadahira, Shigeyuki Kawa, Sen-itiroh Hakomori
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A method of inhibiting tumor cell chemotactic and/or chemoinvasion motility comprising contacting the tumor cell with an inhibitory amount of an agent selected from the group consisting of sphingosine-1-phosphate, derivatives of sphingosine-1-phosphate and mimetics of the sphingosine-1-phosphate or of the derivatives. A method of inhibiting phagokinetic activity of tumor cells and neutrophils comprising contacting the cells with a phagokinetic inhibitory amount of an agent selected from the group consisting of sphingosine-1-phosphate, derivatives of sphingosine-1-phosphate, and mimetics of the sphingosine-1-phosphate or of the derivatives. A method of inhibiting tumor cell metastasis comprising administering to a host in need of treatment a metastasis inhibitory amount of an agent selected from the group consisting of sphingosine-1-phosphate, derivatives of sphingosine-1-phosphate, and mimetics of the sphingosine-1-phosphate or of the derivatives, and pharmaceutically acceptable salts of the agent. A method of inhibiting inflammation due to motility and invasion into blood vessel walls of neutrophils comprising administering to a host in need of treatment an inflammation inhibitory amount of an agent selected from the group consisting of sphingosine-1-phosphate, derivatives of sphingosine-1-phosphate, and mimetics of the sphingosine-1-phosphate or of the derivatives, and pharmaceutically acceptable salts of the agent. A method of preparing sphingosine-1-phosphate and its derivatives.
A method of inhibiting tumor cell chemotactic motility comprising contacting said tumor cells with an inhibitory amount of sphingosine-1-phosphate or a derivative of sphingosine-1-phosphate, wherein said derivative of sphingosine-1-phosphate is selected from the group consisting of N,N-dimethylsphingosine-1-phosphate, N,N,N,-trimethylsphingosine-1-phosphate, N-acylsphingosine-1-phosphate, sphingosine-1,3-diphosphate, sphingosine-3-phosphate, sphingosine-1-thiophosphate, N,N-dimethylsphingosine-1-thiophosphate, N-acylsphingosine-1-thiophosphate and N,N,N-trimethylsphingosine-1-thiophosphate.
A method of inhibiting tumor cell chemoinvasion comprising contacting said tumor cells with an inhibitory amount of sphingosine-1-phosphate or a derivative of sphingosine-1-phosphate, wherein said derivative of sphingosine-1-phosphate is selected from the group consisting of N,N-dimethylsphingosine-1-phosphate, N,N,N,-trimethylsphingosine-1-phosphate, N-acylsphingosine-1-phosphate, sphingosine-1,3-diphosphate, sphingosine-3-phosphate, sphingosine-1-thiophosphate, N,N-dimethylsphingosine-1-thiophosphate, N-acylsphingosine-1-thiophosphate and N,N,N-trimethylsphingosine-1-thiophosphate.
A method of inhibiting phagokinetic activity of tumor cells and neutrophils comprising contacting said cells with a phagokinetic inhibitory amount of sphingosine-1-phosphate or a derivative of sphingosine-1-phosphate, wherein said derivative of sphingosine-1-phosphate is selected from the group consisting of N,N-dimethylsphingosine-1-phosphate, N,N,N,-trimethylsphingosine-1-phosphate, N-acylsphingosine-1-phosphate, sphingosine-1,3-diphosphate, sphingosine-3-phosphate, sphingosine-1-thiophosphate, N,N-dimethylsphingosine-1-thiophosphate, N-acylsphingosine-1-thiophosphate and N,N,N-trimethylsphingosine-1-thiophosphate.
A method of inhibiting tumor cell metastasis comprising administering to a host in need of treatment a metastasis inhibitory amount of an agent selected from the group consisting of sphingosine-1-phosphate and a derivative of sphingosine-1-phosphate, and pharmaceutically acceptable salts of said agent, wherein said derivative of sphingosine-1-phosphate is selected from the group consisting of N,N-dimethylsphingosine-1-phosphate, N,N,N,-trimethylsphingosine-1-phosphate, N-acylsphingosine-1-phosphate, sphingosine-1,3-diphosphate, sphingosine-3-phosphate, sphingosine-1-thiophosphate, N,N-dimethylsphingosine-1-thiophosphate, N-acylsphingosine-1-thiophosphate and N,N,N-trimethylsphingosine-1-thiophosphate.
Dependencies are inferred from the claim text.