Human manganese superoxide dismutase (hMn-SOD)
AssigneeBoehringer Ingelheim International GmbH
InventorsKonrad Heckl, Walter Spevak, Elinborg Ostermann, Andreas Zophel, Edeltraud Krystek, Ingrid Maurer-Fogy, Maria J. Wiche-Castanon, Christian Stratowa, Rudolf Hauptmann
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Abstract
The present invention relates to a method of preparing human Mn-superoxide dismutase (hMn-SOD) by genetic engineering, the DNA sequences which code for this enzyme, suitable vectors which contain these DNA sequences and host cells which can express these DNA sequences, and the enzyme hMn-SOD itself. Suggestions as to the use of this enzyme are also described.
Claims7
A substantially pure polypeptide having the enzymatic, biochemical and immunological properties of human manganese superoxide dismutase and comprising the amino acid sequence:
- ##STR17## wherein Lys (29) may be substituted by Gln.
Dependencies are inferred from the claim text.