Iodinated aliphatic emulsions for X-ray contrast
OwnerDaniel L. Rubininventor
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Abstract
Contrast agents comprising stable aqueous emulsions of iophendylate and their use in radiological examination of the small and large intestine after oral administration are described.
Claims13
A process for visualization of the GI tract of a mammal comprising administering to the mammal a diagnostically effective amount of a contrast agent comprising an aqueous emulsion of an iodinated compound which iodinated compound is an aliphatic carboxylic acid of from 6-17 carbon atoms in the aliphatic chain exclusive of any branching in said aliphatic chain, said carboxylic acid being (a) iodinated directly or by incorporation therein of an iodinated substituent and (b) slightly soluble in water and which emulsion shows no visible evidence of separation into oil and water phases in the GI tract for at least about one hour as demonstrated by radiographic examination.
A process for visualization of the GI tract of a mammal comprising administering to the mammal a diagnostically effective amount of a contrast agent comprising an aqueous emulsion of an iodinated compound convertible at least in part in the GI tract to an aliphatic carboxylic acid of from 6 to 17 carbon atoms in the aliphatic chain exclusive of any branching in the aliphatic chain, which compound is (a) iodinated directly in the aliphatic chain of the carboxylic acid or by incorporation therein of an iodinated substituent and (b) slightly soluble in water and which emulsion shows no visible evidence of separation into oil and water phases in the GI tract for at least about one hour as demonstrated by radiographic examination.
Dependencies are inferred from the claim text.