Leucocyte depleting filter device and method of use
AssigneePall Corporation
InventorsThomas C. Gsell, Thomas Bormann, Vlado I. Matkovich
Life of this patent
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Abstract
Leucocyte depletion filter assemblies decrease the leucocyte content of a biological fluid in an extracorporeal circuit. These filter assemblies are suitable for use in an extracorporeal circuit. Methods for removing leucocytes and other deleterious matter are also disclosed. The removal medium used in these assemblies and methods may be pleated structures which have been subjected to gas plasma treatment, improving the amount of leucocytes removed and increasing the amount of platelets which pass through the medium.
Claims32
A leucocyte depletion filter assembly for removing leucocytes and other deleterious mater from a biological fluid in an extracorporeal circuit, the filter assembly comprising:
- a housing having an inlet and an outlet and defining a liquid flow path between the inlet and the outlet, and
- a pleated medium positioned inside the housing across the liquid flow path and including a fibrous means for decreasing the leucocyte content of the liquid, the surface of said fibrous means being modified by exposure to a gas plasma stream, wherein said fibrous means is capable of permitting the passage of red blood cells and platelets therethrough.
The leucocyte depletion filter assembly for removing leucocytes and other deleterious matter from a biological fluid in an extracorporeal circuit, the filter assembly comprising:
- a housing having an inlet, an outlet, and a vent and defining a liquid flow path between the inlet and the outlet;
- a degassing mechanism communicating with the vent for removing gas from the biological fluid;
- and
- a pleated fibrous medium positioned in the housing across the liquid flow path, the surface of said fibrous medium having been modified by exposure to a gas plasma stream, said fibrous medium being capable of decreasing the leucocyte consent of the biological fluid and permitting the passage of red cells and platelets therethrough.
A leucocyte depletion filter assembly for removing leucocytes and other deleterious matter from a biological fluid in an extracorporeal circuit, the filter assembly comprising:
- a generally cylindrical housing having first and second chambers, an inlet which allows tangential inflow into the first chamber, an outlet which allows outflow from the second chamber, and a vent;
- a porous degassing element position end between the first and second chambers to remove gas from the biological fluid;
- a liquophobic membrane covering the vent and communicating with the degassing element to allow gas but not liquid to flow through event;
- and
- a hollow, cylindrical porous medium positioned in the second chamber and comprising a pleated fibrous medium having a CWST of 52 dynes/cm or greater, the surface of said fibrous medium having been modified by exposure to a gas plasma stream, said fibrous medium being capable of decreasing the leucocytes content of the biological fluid and permitting the passage of red cells and platelets therethrough, and the interior of the hollow pours medium communicating with the outlet.
A method for removing leucocytes and other deleterious matter from a biological fluid comprising:
- passing the biological fluid through a pleated fibrous medium in an extracorporeal circuit, the surface of the fibrous medium having been modified by exposure to a gas plasma stream, said fibrous medium being capable of decreasing the leucocytes content of the biological fluid and permitting the passage of red cells and platelets therethrough.
A method for removing leucocytes and other deleterious matter from a biological fluid comprising:
- directing biological fluid in an extracorporeal circuit through a housing;
- separating gas for the biological fluid;
- venting the gas for the housing;
- passing the biological fluid through a fibrous means positioned within the housing, the surface of said fibrous means having been modified by exposure to a gas plasma stream, thereby decreasing the leucocyte content of the biological fluid while permitting the passage of red blood cells and platelets.
A method of treating blood in an extracorporeal circuit comprising:
- directing the blood through a housing;
- separating gas from the blood;
- venting the gas from the housing;
- passing the blood through a fibrous medium positioned within the housing, the surface of said fibrous medium having been modified by exposure to a gas plasma stream, thereby decreasing the leucocyte consent of the blood while permitting the passage of red blood cells and platelets.
A method for removing leucocytes and other deleterious matter from a biological fluid comprising:
- directing biological fluid in an extracorporeal circuit through a pleated fibrous medium which allows platelets and red cells to pass therethrough, at a flow rate of up to six liters per minute, the surface of said fibrous medium having been modified by exposure to a gas plasma stream;
- and
- removing a clinically or therapeutically significant amount of leucocytes from the biological fluid.
Dependencies are inferred from the claim text.